Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo

Effects of Pravastatin in Adriamycin-Induced Nephropathy in Rats

The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus pravastatin (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 aft...

Abrogation of adriamycin-induced cardiotoxicity by selenium in rabbits.

Adriamycin-induced cardiomyopathy in rabbits was produced by intravenous injections of the drug with a short therapeutic schedule (3 mg/kg body wt administered as four intermittent doses). Animals receiving selenium supplementation of Adriamycin showed preservation of the normal pattern of the heart histologic picture. The protective effect of selenium was accompanied by increased selenium leve...

Liposomal protection of adriamycin-induced cardiotoxicity in mice.

The pharmacological and therapeutic effects of Adriamycin entrapped in positively charged and negatively charged lipo somes were compared with those of free Adriamycin in mice. Liposomes were composed of phosphatidylcholine and choles terol mixed with stearyl amine (positive charge) or phosphatidylserine (negative charge). Positive liposomes with entrapped Adriamycin effectively retarded the in...

Schisandra chinensis protects against adriamycin-induced cardiotoxicity in rats.

BACKGROUND Adriamycin (ADR) is an effective chemotherapeutic agent against cancers but its clinical use is limited due to its cardiotoxicity. It has been suggested that the pathogenesis involves inhibition of nucleic acid and protein synthesis, free radical formation and lipid peroxidation. Schisandra (SC) has strong antioxidant activity. We investigate the protective effects of SC on adriamyci...

Adriamycin-induced cardiotoxicity (cardiomyopathy and congestive heart failure) in rats.